Minnesota Twins at Cleveland Guardians odds, picks and predictions

The Minnesota Twins (43-34) and Cleveland Guardians (37-34) continue their 5-game series on Wednesday at Progressive Field with the 1st pitch set for 7:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Twins vs. Guardians odds with MLB picks and predictions.

Season series: Minnesota leads 5-4.

The Twins and Guardians split a Tuesday doubleheader after Minnesota won  Monday’s opener 11-1. Minnesota is 4-1 with a 1.43 ERA in its last 5 games.

Cleveland continues a homestand that opened with 3 straight losses to the Boston Red Sox. The Guardians are 1-6 with a lowly .553 OPS in their last 7 games.

Twins at Guardians projected starters

RHP Dylan Bundy vs. RHP Cal Quantrill

Bundy (4-4, 4.80 ERA) owns a 1.28 WHIP, 1.8 BB/9 and 6.9 K/9 through 60 IP in 12 starts.

Has allowed just 2 runs on 8 hits in his last 14 IP.
Excels against lefty bats (.224 batting average allowed 2020-22) and is facing a Cleveland lineup whose left-handers pound right-handed pitchers (league-best .883 OPS).

Quantrill (4-4, 3.76 ERA) makes his 14th start. He has a 1.27 WHIP, 2.9 BB/9 and 5.6 K/9 in 76 2/3 IP.

Owns a 2.87 ERA, 1.05 WHIP in his last 5 starts at home.
Has benefited from a .275 batting average on balls in play and a home-runs-on-fly-balls rate of 8.5%.

Twins at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 9:30 a.m. ET.

Money line: Twins -105 (bet $100 to win $105) | Guardians -115 (bet $115 to win $100)
Run line (RL): Twins -1.5 (+155) | Guardians +1.5 (-190)
Over/Under (O/U): 8.5 (O: -115 | U: -107)

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Twins at Guardians picks and predictions


Twins 5, Guardians 4

Money line

There are several crisscrossing value indicators for and against both sides in this series. The edge for Wednesday’s matchup is on the TWINS (-105) due to some fade-Quantrill indicators and the tightened bullpens after Tuesday’s double-dip. The latter brings in some lean on Cleveland’s bullpen being somewhat overvalued in general.

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Run line/Against the spread

PASS. The Minnesota money-line play makes for the best side in this one.


With fade leanings against Cleveland and a warmed-up day in Northeast Ohio, the OVER 8.5 (-115) offers some leverage. The double-barreled bullpen fatigue plays into this play as well.

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Author: Naomi Berry